CELLULAR ANGİOFİBROMA

• This is an uncammon distinctive soft tissue tumor that in females most commonly arises in the vulva rare tumors have arisen in the vagina, parineum, inguinal region, or urethra.
• The patents are of peproductive or postmenopausal age (mean,46 years) and present with a superficial mass. The tumors are successfully treated by local excision; one recurred locally.
• In the largest series, the tumors measured 0.6-12 (median 2.8) cm and were usually well circumscribed, with a solid, white, tan, or grey sectioned surface.
• Microscopic examnation reveals a cellular proliferation of spindle cells arranged in short interesting fascicles, numerous small to medium-sized, thick-walled, often hyalinized, blood vessels, and short wispy collagen bundles. The spindle cells have scanty eosinophilic cytoplasm and bland nuclei. Mitotic figures are usually uncommon.
• Fat is present in about 25& of cases, but usually accounts for less than 5% of the tumor. Hypocellular areas related to areas of edema, myxoid change, or hyalinization may be present.
• Unusual to rare findings include an infiltrative border, absence of thick-walled vessels, dilated hemangiopericytomatous vessels, vague nuclear palisading, mild cytologic atypia, multinucleated cells (like those in symplastic leiomyomas), frequent mitotic figures (up to 11 MFs/10 HPFs), and stromal lymphoid aggregates.
• The spindle cells are immunoreactive for vimentin, CD34, smooth muscle actin, and desmin in approximately 100%, 50%, 20&, and 10% of caces, respectively, Nuclear staining for ER, PR, or both is present in about half the caces. Staining for keratin, EMA, and S100 protein is negative.