CLİNİCAL FEATURES AND BEHAVİOR
- This tumor is the least common variant of ovarian carcinoid. Bases on the only series of such cases (Baker et al.), the age range has varied frıom 14 to 74 years and the clinical presentation is nonspecific.
- Most ofthe reported tumors have been clinically benign, except for several tumors with a carcinomatous component (see below) that had extraovarian spread at presentation and a fatal course.
PATHOLOGİCAL FEATURES
- The tumors, which range up to 30 cm in diameter, may be entirely solid but more commonly form a mural mass in a mature cystic teratoma or other type of cystic ovarian tumor (mucinous borderline tumor or carcinoma, borderline Brenner tumor, epidermoid cyst). Two tumors were intimately admixed with yolk sac tumor.
- Mucinous carcinoids can be divided into there categories based on their microscopic appearance:
- 'Well-differentiated' tumors are composed of small glands, sometimes lying within pools of mucin, lined by goblet cells and differentiation. The cells show minimal atypia.
- 'Atypical' tumors contain crowded to confluent glands, small islands with a cribriform pattern, and scattered microcystic glands, with cells similar to those in the well-differentiated tumors and mild to moderate atypia.
- 'Carcinoma arising in mucinous carcinoid' are camposed of solid nests or closely packed glands composed of mucin-poor cells that are markedly atypical and mitotic. Signet-ring cells are also usually prominent. Foct of well-differentiated or atypical carcinoid are typically present.
- The tumor cells are variably immunoreactive for synaptophysin and chromogranin. One or more intestinal-type polypeptide hormones have also been found in some tumors.
- Other elements present in some tumors have been noted above. Additionally, occasional tumors have contained a component of insular, trabecular, or strumal carcinoid.
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