- These tumors have a similar frequency to insular carcinoids, and occur throughout adult life, The clinical presentation is usually related to the presence of an adnexal mass. One case had peritoneal implants of struma at the time of oophorectomy.
- The carcinoid syndrome has been found in only rare cases, but manifestations suggesting function of the thyroid component have been present in 10 %. Chronic constipation relieved by removal of the tumor has been a symptom in rare cases.
- The tumors are almost always clinically bening. There has been only one reported fatality. 2.5 years postoperatively.
Pathological features
- The sectioned surface is usually homogeneous, yellow or tan, and solid, but may ve variably cystic. The strumal and carcinoid components are each growly recognizable in occasional cases.
- On microscopic examination the tumors consist of two components, which are usually admixed but occasionally only contigunous, one being a trabecular or mixed trabecular-insular carcinoid, and the other typical truma ovarii.
- Glands or cysts lined by mucinous epithelium are seen in half the cases and bay be conspicuous; rarely there may be an admixed mucinous carcinoid.
- The tumors are usually immunoreactive for chromogranin, synaptophsin,serotonin prostatic acid phosphatase and in 40%, neurohormonal peptides, including peptide YY in patiens with constipation. The strumal component is typically positive for thyroglobulin and TFF-1.
Hiç yorum yok:
Yorum Gönder